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Enzymatically active LCAT was present in human CSF as well as PLTP activity and mass; no CETP mass was detected. On the contrary, increasing cellular cholesterol concentrations by adding β-VLDL to Cos1 cells causes a decrease of the secretion of the soluble form of APP (s APP).
Its most important functions are to redistribute lipids needed for neurite growth through receptor-mediated uptake and to interact with the amyloid β peptide (4–7).
We investigated the lipoprotein distribution and composition in cerebrospinal fluid (CSF) in a group of patients with Alzheimer's disease (AD) or affected by other types of dementia in comparison to non-demented controls. In analogy with the metabolism of lipids in the peripheral circulation, cerebrospinal fluid (CSF) lipids are transported by lipoproteins.
We found slightly decreased apolipoprotein (apo)E and cholesterol concentrations in CSF of AD patients and moderately increased apo A-I concentrations, while in patients suffering from other types of dementia the apo A-I CSF concentration was increased. Although several reports describe the composition of CSF lipoproteins (4, 8–12), their detailed structure and functions are only poorly understood.
She also holds the prestigious Commodore status with Cunard Academy.
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In this study, we carried out a detailed analysis of lipids and lipoproteins in CSF collected from patients affected by AD, by other forms of dementia, or from non-demented controls in order to look for major differences in the lipid and lipoprotein composition among the different diagnostic groups.